1980 Event World Health Organization announced smallpox had been eradicated 1800 Event Dr. Benjamin Waterhouse gives 1st cowpox vaccination to his son to prevent smallpox 1799 Event Edward Jenner's smallpox vaccination is introduced 1796 Event 1st smallpox inoculation administered, by Edward Jenner 1754 Birthday Benjamin Waterhouse, physician, smallpox vaccine pioneer 1721 Event Dr. Zabdiel Boylston gives 1st smallpox inoculations in America 1721 Event Smallpox vaccination 1st administrated 1677 Event 1st medical publication in America (pamphlet on smallpox), Boston