| January 17 | Cesare Borgia returns in triumph to Rome from Romagna |
| April 23 | Portuguese navigator Pedro Cabral and 6 ships return to Lisbon |
| May 20 | Joao da Nova Castell discovers Ascension Islands |
| July 15 | Explorer Pedro Cabral back in Lisbon |
| July 27 | Copernicus formally installed as canon of Frauenberg Cathedral |
| October 13 | Maximilian of Austria and Louis XII sign Treaty of Trente |
| October 15 | English crown prince Arthur marries Catharina of Aragon |
| November 4 | Philip de Blank and Juana "la Loca" depart to Spain |
