| April 19 | 2nd Parliament of Spiers bans Lutheranism |
| April 22 | Treaty of Saragosa: Spain and Portugal divide eastern hemisphere |
| May 6 | Battle at Gogra: Mogol emperor Babur beats Afghans and Bengals |
| May 27 | 30 Jews of Posing Hungary, charged with blood ritual, burned at stake |
| June 9 | Zurich declares war on Catholic kantons |
| June 18 | Blackfriars begin: Henry VIII and Catharina of Aragon |
| June 21 | Battle at Landriano: Leyva beats France |
| June 24 | Zurich and catholic kantons sign Peace of Kappel |
| June 29 | Emperor Karel V and Pope Clemens VII sign Treaty of Barcelona |
| July 26 | Francisco Pizarro appointed governor of Peru |
| August 3 | "Ladies' Peace" (treaty of Cambrai)-emperor Charles V and King French I |
| September 22 | Cardinal Thomas Wolsey lays-off English Lord Chancellor |
| October 1 | Meeting between Maarten Luther and Huldrych Zwingli |
| October 14 | Sultan Suleiman II ceases Vienna |
| October 26 | Thomas More appointed English Lord Chancellor |
| November 4 | English cardinal Thomas Wolsey arrested |
