| February 16 | Dutch Grand Pensionary advisor Johan de Witt marries Wendela Bicker |
| March 25 | Christiaan Huygens discovers Titan, (Saturn's largest satellite) |
| April 4 | Battle at Postage Farina, Tunis: English fleet beats Barbarian pirates |
| April 7 | Fabio Chigi replaces Pope Innocent X as Alexander VII |
| April 26 | Dutch West Indies Co denies Peter Stuyvesant's desire to exclude Jews from New Amsterdam |
| April 28 | English Admiral Blake beats Tunen pirate fleet |
| May 10 | Jamaica captured by English |
| June 13 | Adriana Nooseman-van de Bergh is 1st actress in Amsterdam theater |
| July 27 | Jews of New Amsterdam petition for a Jewish cemetery |
| July 27 | Netherlands and Brandenburg sign military treaty |
| July 29 | Biggest townhall in the world opens in Amsterdam |
| July 30 | Dutch troops occupy Fort Assahudi Seram |
| August 9 | Lord Protector Cromwell divides England into 11 districts |
| August 28 | New Amsterdam and Peter Stuyvesant bars Jews from military service |
| August 29 | Swedish king Karel X Gustaaf occupies Warsaw |
| September 8 | Swedish king Karel X Gustaaf occupies Warsaw |
| September 26 | Peter Stuyvesant recaptures Dutch Ft. Casimir from Swedish in Delaware |
| October 9 | Swedish king Karel X Gustaaf occupies Krakow |
| October 15 | Jews of Lublin are massacred |
| October 19 | Swedish King Karel X Gustaaf occupies Krakow |
| November 3 | England and France sign miltary and economic treaties |
| November 24 | English Lord Protector Cromwell bans Anglicans |
| December 4 | Middelburg Netherlands forbids building of synagogue |
