| January 5 | Central America proclaims annexation to Mexican Empire |
| January 7 | 1st printing in Hawaii |
| January 7 | Liberia colonized by Americans |
| February 4 | Free American Blacks settle Liberia, West Africa |
| February 9 | American Indian Society organizes |
| February 23 | Boston is incorporated as a city |
| March 9 | Charles Graham of New York patents artificial teeth |
| March 16 | Composer Gioacchino Rossini marries Spanish soprano |
| March 19 | Boston, Massachusetts incorporated as a city |
| March 22 | Gioacchino Rossini marries Isabella Colbran in Bologna |
| March 22 | New York Horticultural Society founded |
| March 30 | Congress combined East and West Florida into Florida Territory |
| May 1 | John Phillips becomes 1st mayor of Boston |
| May 3 | Society for Propagation of Faith starts (Lyon, France) |
| May 24 | Battle of Pichincha, Bolivar secures independence of Quito from Spain |
| May 30 | House slave betrays Denmark Vesey conspiracy (37 blacks hanged) |
| June 9 | Charles Graham patents false teeth |
| June 16 | Denmark Vesey, leads slave rebellion in South Carolina |
| June 18 | Part of US-Canadian boundary determined |
| June 29 | Prince Charles Bonaparte marries niece Zenaide Bonaparte |
| July 25 | General Agustin de Iturbide crowned Agustin I, 1st emperor of Mexico |
| July 26 | Secret meeting of Simon Bolivar and Jose de San Martin |
| July 30 | James Varick becomes 1st bishop of Afr Meth Episcopal Zion Church |
| August 10 | Antioch Syria, hit by Earthquake; about 20,000 die |
| September 7 | Brazil declares independence from Portugal (National Day) |
| September 7 | Pedro I, son of king Joao VI, declares Brazil independence |
| October 8 | 1st eruption of Galunggung (Java) sends boiling sludge into valley |
| October 12 | 2nd eruption of Galunggung (Java) destroys summit of mountain |
| October 20 | 1st edition of London Sunday Times |
| October 26 | King Willem I obligates inhabitants of Brussels to use Dutch language |
| December 1 | Dom Pedro crowned emperor of Brazil |
| December 1 | Franz Liszts (11) debut as pianist Isabella Colbran |
| December 2 | In San Salvador, a congress proposes incorporation into US |
| December 6 | Veterinary school in Utrecht opens |
| December 12 | Mexico officially recognized as an independent nation by US |