| January 5 | 1st edition of Amsterdam General Trade Journal (Algemeen Handelsblad) |
| February 18 | More than 100 vessels destroyed in a storm, Gibraltar |
| February 21 | 1st American Indian newspaper in U.S., "Cherokee Phoenix," published |
| February 22 | Russia and Persia sign Peace of Turkmantsjai |
| February 25 | John Quincy Adam's son John marries in White House |
| February 28 | Franz Grillparzer's "Ein Treuer Diener," premieres in Vienna |
| March 24 | Philadelphia and Columbia Railway (1st state owned) authorized |
| April 4 | Casparus van Wooden patents chocolate milk powder (Amsterdam) |
| April 14 | 18-gun sloop "Acorn" sinks off Halifax with 115 men aboard |
| April 14 | 1st edition of Noah Webster's dictionary published |
| April 21 | Noah Webster publishes 1st American dictionary |
| April 26 | Russia declares war on Turkey to support Greece's independence |
| April 27 | Zoological Gardens at Regent's Park London, opens |
| May 13 | U.S. passes Tariff of Abominations |
| May 18 | Battle of Las Piedras, ends conflict between Uruguay and Brazil |
| June 13 | Simon Bolivar proclaimed dictator |
| July 4 | Construction begins on B and O (Baltimore-Ohio) 1st U.S. passenger RR |
| August 24 | Dutch army takes Fort Du Bus in New Guinea |
| August 27 | Uruguay gains independence during Brazil-Argentina peace talk |
| September 20 | Gioacchino Rossini's opera "Le Comte Ory," premieres in Paris |
| December 3 | Andrew Jackson elected 7th president of US |
| December 19 | South Carolina declares right of states to nullify federal laws |
| December 28 | 6.8 earthquake strikes Echigo Japan, 30,000 killed |